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Anti-DcR2/FITC,FITC標記的誘捕受體2抗體

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研盟生物標記抗體“Anti-DcR2/FITC,FITC標記的誘捕受體2抗體“，規(guī)格100ul，保證品質(zhì)，咨詢：

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產(chǎn)品名稱 Anti-DcR2/FITC,FITC標記的誘捕受體2抗體

產(chǎn)品編號 BYK-1694R-FITC

英文名稱 Anti-DcR2/FITC

中文名稱 FITC標記的誘捕受體2抗體

別名 TNFRSF10D; Decoy receptor 2; CD 264; CD264; CD-264; DcR 2; decoy with truncated death domain; ID; TNF receptor related receptor for TRAIL; TNF related apoptosis inducing ligand receptor 4; TNFRSF 10D; TRAIL R4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; TRAILR4; TRIALR 4; TRUNDD; Tumor necrosis factor receptor superfamily member 10d decoy with truncated death domain; Tumor necrosis factor receptor superfamily member 10D precursor; TR10D_HUMAN.

研究領(lǐng)域腫瘤  細胞生物  免疫學(xué)  細胞凋亡  細胞膜受體
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量 36kDa
細胞定位細胞膜
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免疫原 KLH conjugated synthetic peptide derived from human DcR2

亞型 IgG
純化方法 affinity purified by Protein A
儲存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Anti-DcR2/FITC,FITC標記的誘捕受體2抗體產(chǎn)品介紹：Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L, a member of the TNF family, induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was identified and designated DcR2. The DcR2 receptor is 386 amino acids in length and has an extracellular TRAIL binding domain, but lacks intracellular death domain and does not induce apoptosis. Although this receptor binds to the cytotoxic ligand TRAIL, it contains a truncated death domain and functions as an inhibitory receptor. When overexpressed, the DcR2 receptor can protect cells against TRAIL mediated cytotoxicity. Like DR4 and DR5, DcR2 transcript is widely expressed in a variety of normal human tissues but DcR2 is absent in most tumors. Ultraviolet radiation has been shown to upregulate DcR2 expression on human keratinocytes. Over expression of DcR2 attenuated TRAIL induced apoptosis.

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