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上海研盟生物科技有限公司
上海研盟生物科技有限公司
研盟生物標記抗體“Anti-IL-2R gamma/FITC,FITC標記的白介素2受體γ鏈抗體“，規格100ul，保證品質，咨詢：
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產品名稱 Anti-IL-2R gamma/FITC,FITC標記的白介素2受體γ鏈抗體
產品編號 BYK-2545R-FITC
英文名稱 Anti-IL-2R gamma/FITC
中文名稱 FITC標記的白介素2受體γ鏈抗體
別 名 IL2 Receptor gamma; IL2R gamma; IL 2R gamma; IL-2R gamma; IL-2 receptor gamma precursor; IL2 Receptor gamma; CD132; CD 132; common cytokine receptor gamma chain; Gamma C; gamma(c); IL-2R gamma chain; IL2RG; IMD4; interleukin 2 receptor, gamma; P64; SCIDX; SCIDX1; Cytokine receptor common subunit gamma; Gamma C; gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; IL2RG_HUMAN; Interleukin-2 receptor subunit gamma; p64; SCIDX; SCIDX1.
研究領域 細胞生物 免疫學 信號轉導 細胞膜受體
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow,
產品應用 Flow-Cyt=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 41kDa
細胞定位 細胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-2R gamma
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-IL-2R gamma/FITC,FITC標記的白介素2受體γ鏈抗體產品介紹：Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins.
In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6.
The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement. Mutation of IL2R gamma has been determined to be the cause of severe X-linked combined immunodeficiency (X SCID), a disease that is characterized by the absence of T cells and NK cells.
Anti-IL-2R gamma/FITC,FITC標記的白介素2受體γ鏈抗體相關產品：
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IFABP（Intestinal Fatty acid binding protein） 小腸型脂肪酸結合蛋白抗體
IFABP（Intestinal Fatty acid binding protein） 小腸型脂肪酸結合蛋白抗體
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IFITM1 (interferon induced transmembrane protein 1) 干擾素誘導跨膜蛋白1抗體
human IFN-β (Interferon β) 干擾素-β抗體（抗）
human IFN-α (Interferon α ) 干擾素-α抗體（抗）
IFN-α2b(Interferon alpha 2b) 干擾素α2b抗體
IFN-β (Interferon β) 干擾素-β抗體（大鼠、小鼠）
IFN-γ(Human Interferon γ ）Monoclonal antibody 鼠抗干擾素-γ/IFN-gamma單克隆抗體
IFN-gamma(Interferon gamma )(human) 干擾素-γ抗體（抗）
IFN gamma(Interferon gamma)(mouse,rat) 干擾素-γ抗體 （抗大、小鼠）
IFN-γR/CD119（Interferon-γR receptor） 干擾素-γ受體抗體
IGC (immunoglobulin delta heavy chain constant region membrane-bound form) 兔抗非洲爪蟾IGC抗體
IGF-1R/CD221 （Insulin-like Growth Factor-I Receptor） 胰島素樣生長因子-I受體抗體
IGF-1R（Insulin-like Growth Factor-I Receptor） 胰島素樣生長因子-I受體抗體
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IGFBP-2 (Insulin-like Growth Factor Binding Protein 2) 胰島素樣生長因子結合蛋白-2抗體
IGFBP-3 (Insulin-like Growth Factor Binding Protein 3) 胰島素樣生長因子結合蛋白-3抗體
IGFBP-4/IBP4 ( Insulin-like Growth Factor Binding Protein 4) 胰島素樣生長因子結合蛋白-4抗體
IGFBP-5/IBP5 ( Insulin-like Growth Factor Binding Protein 5) 胰島素樣生長因子結合蛋白-5抗體
IGF-I 胰島素樣生長因子-I抗體
IGF-II/IGF2 胰島素樣生長因子-II抗體
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IKB α (Inhibitor of KBα) KB抑制蛋白α抗體
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IKI3 family protein 擬南芥IKI3抗體
IL-9(Interleukin-9) 白介素9抗體
IL-10(Interleukin-10) 白介素10抗體
IL-11(Interleukin-11) 白介素11抗體
IL-10Ra/IL10RA/CD210(Interleukin-10 Receptor) 白細胞介素-10受體a抗體
IL-10Rβ/IL-10R2/CDw210b(Interleukin-10 receptor subunit beta) 白細胞介素-10受體β抗體
IL-12(Interleukin-12)mouse ret 白介素12抗體（白細胞介素-12）
IL-12(Interleukin-12)human 抗白介素12抗體()
IL-12Rβ1/CD212(Interleukin-12 receptor subunit beta-1) 白細胞介素-12受體β1抗體
IL-12Rβ2(Interleukin-12 receptor subunit beta-2) 白細胞介素-12受體β2抗體
IL-13(Interleukin-13) 白介素13抗體
IL-14/Taxilin alpha 白介素14抗體(白細胞介素-14)
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