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Anti IDH2(R172G) Mouse Monoclonal Antibody

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參考價: ￥ 4800

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IDH2(R172G)[26231][100ul]CatalogNumber:26231GeneSymbol:IDH2

詳細介紹

IDH2 (R172G) [26231]
[100ul]

Catalog Number: 26231

Gene Symbol: IDH2; D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH

Description: Anti IDH2(R172G) Mouse Monoclonal Antibody

Background: Isocitrate dehydrogenase (IDH) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. The isocitrate and isopropylmalate dehydrogenases family has three members, IDH1, IDH2 and IDH3. IDH2 plays a role in intermediary metabolism and energy production. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2). Somatic mosaic mutations of this protein have also been found associated to Ollier disease and Maffucci syndrome, and R172G IDH2 mutations do exist in diffusely infiltrative gliomas.

Immunogen: A synthetic peptide from the internal region of IDH2 which includes the mutation of R172G, human origin.

Applications: ELISA, WB, IHC

Recommended Dilutions:
ELISA: 1:1000-1:5000
WB: 1:100-1:1000
IHC: 1:50-1:100

Concentration: 1 mg/ml

Host: mouse

Format: Liquid

Clonality: Monoclonal

Isotype:

Purity: Purified from ascites

Storage buffer:

Preservative: no

Constituents: PBS (without Mg²⁺ ａnd Ca²⁺), pH 7.4, 150 mM NaCl, 50% glycerol

Species Reactivity: recognizes R172G mutant, but not wild-type IDH2 of vertebrates.

Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles

Download Datasheet:

Western blot:

Western blot analysis of recombinant IDH2(R172G) and wildtype proteins. Purified His-tagged IDH2(R172G) (lane 1) and corresponding wild-type IDH2 protein (lane 2) were blotted with anti IDH2 (R172G) monoclonal antibody (Cat. #26231).

Immunofluorescence:

Immunofluorescence of cells expressing IDH2 proteins with anti IDH2(R172G) antibody. HEK293T cells were transfected with pCDNA3-GFP IDH2(WT) plasmid (left column) or pCDNA3-GFP IDH2(R172G) plasmid (right column), then fixed and stained with anti IDH2(R172G) monoclonal antibody (Cat. #26231).

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