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武漢紐斯特生物科技有限公司
武漢紐斯特生物科技有限公司
cGMPCatalogNumber:26001-1Description:Anti-cGMPMouseMonoclonalAntibodyBackground:cGMPisaubiquitoussecondmessengermediatingcellularresponsestovariousexogenousandendogenoussignalingmolecules
cGMP
Catalog Number: 26001-1
Description: Anti-cGMP Mouse Monoclonal Antibody
Background: cGMP is a ubiquitous second messenger mediating cellular responses to various
exogenous and endogenous signaling molecules. cGMP regulates physiological processes by
activating protein kinases, gating specific ion channels, and modulating cellular cyclic nucleotide
concentrations through phosphodiesterases. The conversion of GTP to cGMP is catalyzed by
guanylyl cyclases (GCs). There are two types of GCs in mammals: the soluble and the membrane-bound
GCs. The soluble GCs are generally activated when nitric
oxide binds to the attached prosthetic heme group. Seven membrane-bound GCs (also named
transmembrane or particulated GCs) have been identified in the human genome. GC-A and
GC-B are natriuretic peptide receptors. GC-C can be activated by bacterial heat-stable enterotoxins,
guanylin and uroguanylin. The activity of transmembrane GCs can also be
modulated by other receptor signals through intracellular signaling pathways.
Immunogen: cGMP
Tested applications: ELISA, WB, IHC
Recommended dilutions: ELISA 1:1000-1:5000, WB 1:1000-1:2000,
Host: mouse Clonality: Monoclonal
Isotype: IgG
Purity: Purified from ascites
Format: Liquid
Storage buffer:
Preservative: no
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles
Sensitivity
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