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當(dāng)前位置:珀金埃爾默醫(yī)學(xué)診斷產(chǎn)品(上海)有限公司>>>>Dihydroxyphenylethylamine, 3,4-[7-3H]-, 250µCi (9.25MBq)

Dihydroxyphenylethylamine, 3,4-[7-3H]-, 250µCi (9.25MBq)

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更新時間:2022-10-15 12:05:04瀏覽次數(shù):73次

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產(chǎn)品簡介

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the 7 position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors. This product has a s......

詳細(xì)介紹

Dihydroxyphenylethylamine binds dopamine receptors, a class of GPCRs in the central nervous system. Dopamine receptors are implicated in motivation, pleasure, cognition, memory, and learning and are potential drug targets for schizophrenia, Parkinson's disease, and a variety of other psychiatric and neurological conditions.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET131:

  1. Oaks AW, Frankfurt M, Finkelstein DI, Sidhu A (2013) Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function. PLoS ONE 8(4): e60378.
  2. Oaks AW, Marsh-Armstrong N, Jones JM, Credle JJ, Sidhu A (2013) Synucleins Antagonize Endoplasmic Reticulum Function to Modulate Dopamine Transporter Trafficking. PLoS ONE 8(8): e70872.

規(guī)格

濃度 1.0 - 10 mCi/mL
檢測方法 Radiometric
新鮮的很多天 Second Monday in April and October
標(biāo)簽位置 Specifically Labeled
分子量 153.2
產(chǎn)品品牌名稱 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受體類型 Dopamine
運(yùn)輸條件 干冰
特殊訂購信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治療領(lǐng)域 CNS & Neurologic
產(chǎn)品尺寸 250 µCi

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