<small id="isiu8"></small>

<noscript id="isiu8"></noscript>

當前位置：上海勁馬生物科技有限公司>>生物試劑>>酶試劑>>復合蛋白酶/復合酶/Compound proteinase

復合蛋白酶/復合酶/Compound proteinase

返回列表頁

參考價

面議

具體成交價以合同協(xié)議為準

產(chǎn)品型號M0127

品牌

廠商性質(zhì)生產(chǎn)商

所在地上海市

在線詢價收藏產(chǎn)品查看聯(lián)系電話

聯(lián)系方式：楊經(jīng)理查看聯(lián)系方式

更新時間：2025-01-13 11:47:06瀏覽次數(shù)：119次

聯(lián)系我時，請告知來自環(huán)保在線

產(chǎn)品分類 品牌分類

  生物試劑

蛋白質(zhì)試劑

氨基酸試劑

酶試劑

全部產(chǎn)品列表

暫無信息

上海勁馬生物科技有限公司

經(jīng)營模式：生產(chǎn)廠家

商鋪產(chǎn)品：307條

所在地區(qū)：上海上海市

聯(lián)系人：楊經(jīng)理（經(jīng)理）

詢價 給他留言

產(chǎn)品簡介

BR，120u/mg

詳細介紹

Description
Biochem/physiol Actions SID 852843 is an inhibitor of West Nile Virus NS2B-NS3 proteinase. Flaviviruses, such as West Nile and Dengue, are a threat to humans from both public health and bioterrorism perspectives. The NS3 proteinase is essential for flaviviral maturation. Inhibitors of NS3 are sought for treatment and prophylactic therapeutics. The NIH molecular library was screened for activity against West Nile Virus NS3, resulting in the discovery of SID 852843. This compound inhibits the NS3 proteinase of West Nile, but not of Dengue type 2 virus. SID 852843 is a reversible, allosteric inhibitor of the formation of the functional conformation of the NS3 proteinase. This is the first flaviviral proteinase inhibitor with the potential to lead to a drug. Aprotinin is an efficient inhibitor of NS3, but it is not selective and has low penetration into cells, limiting its potential for therapeutic use.

Properties
assay ≥98% （HPLC）
form powder
color white to off-white
solubility DMSO: 10 mg/mL
storage temp. 2-8°C

Safety
WGK Germany NWG

References
reference Motlekar, N., et al., Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases. Assay Drug Dev. Technol. 6, 395-405, （2009）
Johnston, P.A., et al., HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile Virus. Assay Drug Dev. Technol. 5, 737-750, （2007）

Printable Reviews
Product ReviewsReview This Product